セミナー情報

We are investigating multiple topics related to plant disease resistance and to the functional mechanics of proteins with LRR (leucine-rich repeat) domains. We have been studying FLS2, a transmembrane LRR-kinase protein that is the plant receptor of bacterial flagellin, as well as EFR, the plant receptor LRR-kinase for bacterial EF-Tu. Our dissection of specific receptor sub-domains and their contributions to signaling and to protein-protein interactions will be discussed. An algorithm will be described that detects regions of conservation on the predicted surface of folded LRR domains as a means to identify candidate functional domains within the LRR. Lastly, or work on the roles of poly(ADP-ribosyl)ation in the defense signaling pathways elicited by flagellin or EF-Tu will be described.

1. Dunning, F.M., W. Sun, K.L. Jansen, L. Helft and A.F. Bent, 2007. Identification and mutational analysis of Arabidopsis FLS2 Leucine-Rich Repeat domain residues that contribute to flagellin perception. Plant Cell. 19:3297-3313.
2. Adams-Phillips, L., A.G. Briggs and A.F. Bent, 2009. Disruption of poly(ADP-ribosyl)ation mechanisms alters responses of Arabidopsis thaliana to biotic stress. Plant Physiol. 152:267-280.