Engineering mammalian lifecycle in vitro

演題

Engineering mammalian lifecycle in vitro

講演者

Nobuhiko Hamazaki, Ph.D (Department of Genome Sciences, University of Washington)

使用言語

Japanese

日時

2026年3月9日(月曜日) 15：00～16：00

場所

L12

内容

Understanding the mechanistic underpinnings of human post-gastrulation development is crucial, as disruptions during this period often result in severe developmental diseases such as neural tube defects, anencephaly, and cardiac malformations.
Despite its importance, research into this stage is significantly restricted due to ethical and technical barriers associated with accessing and studying human in vivo embryos. Consequently, researchers have sought alternative approaches, with human pluripotent stem cell (hPSC)-derived embryo models emerging as a promising solution. As part of this effort, we have established two distinct in vitro models, the RA-gastruloid and the AP-gastruloid, which successfully recapitulate broad aspects of human embryogenesis. This presentation will highlight recent progress using these models to elucidate the complex regulatory mechanisms governing early human development and discuss the potential of these systems to provide foundational insights into the etiology of developmental disorders.

問合せ先

Neural Regeneration and Brain Repair
Matsuda Taito (matsuda.taito@naist.ac.jp)