From Protein Folding to Cognition: a Serendipitous Path of Discovery

演題

From Protein Folding to Cognition: a Serendipitous Path of Discovery

講演者

Dr. Peter Walter (University of California, San Francisco)

使用言語

English

日時

2017年6月6日(火曜日) 11：00～12：30

場所

大セミナー室

内容

A screen for small molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2’s guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.

問合せ先

ストレス微生物科学
木俣 行雄 (kimata@bs.naist.jp)