Modulation of signal function in the NF-kB system

演題

Modulation of signal function in the NF-kB system

講演者

Dr. Michael Naumann (Institute of Experimental Internal Medicine, Otto von Guericke University Magdeburg, Germany)

使用言語

English

日時

2011年2月28日(月曜日) 13：30～

場所

バイオサイエンス研究科 大セミナー室

内容

The transcription factor NF-κB exerts crucial functions in the regulation of innate and adaptive immune responses, wound healing and tissue maintenance and in the development of immune cells. The integral component of the NF-κB system, the IκB kinases (IKK) phosphorylate IκB, thereby tagging it for subsequent ubiquitinylation and proteolytic destruction, this enables DNA-binding NF-κB dimers to enter the nucleus and to program gene expression. Many components of the NF-κB activation pathway have been identified in the recent years, and the functional relevance of the involved signaling proteins was revealed by pharmacological inhibition, siRNA-mediated knockdown or by the analysis of genetically altered mice. Importantly, an involvement of the COP9 signalosome (CSN) in the regulation of NF-κB has been discovered recently in our lab. The CSN is a conserved multiprotein complex, which mainly functions in the control of proteolysis and disease. The CSN regulates the assembly and activity of cullin-RING ubiquitin-ligases (CRLs). The CSN comprise eight subunits with an intrinsic metalloprotease activity, which removes the covalent conjugated regulatory protein Nedd8 from CRLs. In addition, CSN-associated deubiquitinylases (DUBs) affect basal and signal-induced CRL-dependent control of molecules in the NF-κB system.

問合せ先

動物分子遺伝学講座
加藤 順也 (jkata@bs.naist.jp)