English Seminars
The complex path to site-specific actions of Focal Adhesion Kinases
| Title | The complex path to site-specific actions of Focal Adhesion Kinases |
| Lecturer | Dr. Stefan T Arold（King Abdullah University of Science and Technology, Saudi Arabia） |
| Language | English |
| Date&Time | 05/18/2016 (Wed) 15：30～16：30 |
| Venue | L12会議室 |
| Detail | Focal adhesion kinase (FAK) controls adhesion-dependent cell motility, survival, and proliferation, and plays a major role in development and cancer. Interestingly, FAK has different functions in different cellular compartments. For example at focal adhesions, FAK regulates integrin signalling in a kinase-dependent manner, whereas in the nucleus it exerts kinase-independent anti-apoptotic effects. We have combined SAXS with data from x-ray crystallography, NMR, bioinformatics, biochemical and functional analyses, to provide first structural insights into full-length FAK. Through specifically affecting the structural dynamics of FAK, we show that low-probability conformational transitions are of biological importance. Collectively, our data show how the dynamics and allosteric interplay between ligands and FAK’s several domains controls site-specific activity of FAK. Our results reveal how FAK detects the coincidence of multiple signals to generate an environment-specific outcome, and open novel therapeutic opportunities for blocking cancer cell invasiveness through protein-protein interaction inhibitors. |
| Contact | 発生医科学 笹井 紀明 (noriakisasai@bs.naist.jp) |